The Barcelona striker netted his 52nd worldwide goal on his landmark 100th appearance, taking full advantage of a goalkeeping error from a routine corner.
Uruguay snuck by the Egyptians via a late set-piece goal in their opening match of the tournament and went back to the well for their first against the Asian side after 23 minutes.
The win gives Uruguay six points from two matches, trailing leaders Russian Federation - also with six points - only on goal difference.
Speaking following BBC's coverage of the game, former Ivory Coast legend Didier Drogba believes we haven't seen the best of Oscar Tabarez's men just yet, but was not impressed with the quality on show from either side.
Neymar fit for Brazil after World Cup injury fears
The Ticos were the toast of the town in the 2014 World Cup, as they reached the quarterfinals for the first time. Brazil plays its next game on Wednesday against Serbia at 2 p.m.
He scored a volley, had another deflected wide and combined well with Cavani early on - but thereafter Saudi defender Ali Albulayhi acted as his shadow, dispensing several tough challenges and moments of gamesmanship that appeared to rile Suarez.
"We are more than proud because we've reached the knockout stage at three successive World Cups".
"His sense of responsibility is remarkable", Tabarez said of Suarez.
One reason why you shouldn't trust a group table during World Cups is because it often paints a wrong picture.
Cavani almost made it 2-0 for Uruguay with a solo run through the opposing defense but his attempt was blocked by Saudi Arabia goalkeeper Mohammed Alowais.
Shaqiri snatches last-gasp 2-1 win for Swiss over Serbia
Granit Xhaka and Xherdan Shaqiri celebrated their goals by making a nationalist symbol of their ethnic Albanian heritage. Follow live updates from Group E as Serbia take on Switzerland .
Muslera will also tie Ladislao Mazurkiewicz as the player to have made the most appearances for Uruguay at a World Cup.
Live Stream: Watch live on fuboTV. "I hope we win our next match", he said.
"They've got a lot of good players with a lot of experience, and for a lot of them it could be their last chance at a World Cup".
Suarez and Cavani need to bring their A game and demolish the wounded defense of Saudi Arabia. He also has nine goals in his last nine starts for Spain. Salah gives this team a slight edge and that should be the difference as they earn the win.
They were more functional than exhilarating and reliant upon the threat carried by Barcelona's Suarez and strike partner Edinson Cavani.
WTF??? Priest Slaps Crying Baby During A Baptism!
The dad looks pissed , and people can be heard remarking "no no no", "sir, he is scared" and "that's not allowed". Suddenly, the priest appears unable to take it again and deals the hollering baby a quick slap in the face.
The FIFA World Cup 2018 Uruguay v/s Saudia Arabia match will be played at Rostov Arena Rostov-On-Don.