Cancer Immunotherapy Researchers Win 2018 Nobel Prize for Physiology or Medicine

Nobel prize laureates James P. Allison left and Tasuku Honjo are shown during the presentation in Stockholm on Oct. 1

AP Nobel prize laureates James P. Allison left and Tasuku Honjo are shown during the presentation in Stockholm on Oct. 1

In 1982, while working at The University of Texas System Cancer Center, Allison made a breakthrough discovery - identifying the T-cell antigen receptor, which allows T cells to recognize an unusual protein on the surface of another cell. By releasing this brake, the body's own immune system can be stimulated to attack tumors.

The citation for this year's Nobel Prize in Medicine says the two honorees developed therapies for treating cancer.

Allison focused on a protein on the surface of T cells called CTLA-4, discovering that it inhibits the immune cells. Allison and Tasuku Honjo have jointly been awarded the Nobel Prize in medicine or physiology.

In the early 1990s, Allison had been studying a protein called CTLA-4, which sits in the outer layer - the membrane - of an active T-cell and behaves like an off-switch. And more recently, scientists have found that combining the two targets can be even more effective in cancer treatment, particularly in combating melanoma.

Allison said scientists need to better understand "how these drugs work and how they might best be combined with other therapies to improve treatment and reduce unwanted side effects".

'Captain America' Reed can't shield himself from Ryder Cup criticism
At one point, they made, what, six out of eight birdies on the back nine, and only one person was in the hole at a time. Playing against a team like that, that's putting that well, you're going to have to make a lot of birdies.

"I never dreamed my research would take the direction it has", Allison adds. Allison, initially driven only by curiosity about immune cells, had a insane thought: Maybe CTLA-4 can be exploited to fight cancer.

"Targeted therapies don't cure cancer, but immunotherapy is curative, which is why many consider it the biggest advance in a generation", Allison said in a 2015 interview.

In fact, Allison was instrumental in creating the research environment of the current Department of Molecular and Cell Biology at UC Berkeley as well as the department's division of immunology, in which he served stints as chair and division head during his time at Berkeley, said David Raulet, director of Berkeley's Immunotherapeutics and Vaccine Research Initiative (IVRI).

In a statement to reporters after learning of his award, Allison said he was "honored and humbled". Carter announced in 2016 that he no longer needed treatment.

"I was doing basic science to do basic science, but you know, I had the good opportunity to see it develop into something that actually does people good", Allison has said.

EPL: Guardiola insists he is not afraid of Liverpool
City were not expecting him to be available until late November, but his return could well come before this month's global break. Star playmaker Ilkay Gundogan was the star of the show during Man City's win over Cardiff City last weekend.

Allison started his career at MD Anderson in 1977, arriving as one of the first employees of a new basic science research center located in Smithville, Texas.

The physics prize is to be announced Tuesday, followed by chemistry.

Although the concept of using the immune system against cancer arose in the 19th century, initial treatments based on the approach were only modestly effective.

No literature prize is being given this year.

For the first time since 1949, the Swedish Academy has postponed the announcement of the 2018 Nobel Literature Prize until next year, amid a #MeToo scandal and bitter internal dispute that has prevented it from functioning properly.

Canada reaches a trade deal with US & Mexico under new name
The formal NAFTA text is due before Monday in order to meet U.S. congressional notification requirements and allow U.S. Trudeau said it made no sense to sign on to a new NAFTA only to be hit by new tariffs , and is seeking safeguards.

Latest News