Wednesday's match is an incredibly important one, with the two sides tied for first place in Group B. Both sides are now undefeated in the Champions League, with victories coming at the expense of Tottenham Hotspur and PSV Eindhoven.
In addition to missing the Madrid clash, Barca's all-time top scorer will be unavailable for Wednesday's Champions League home match with Inter Milan and the return leg on November 6 - plus a Copa del Rey match against Cultural Leonesa and league contests with Rayo Vallecano and Real Betis.
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Because many of those people, a fairly big percentage of those people are criminals, and they want to come into our country. Mr Trump, who has threatened to close down the U.S. border, said the military would be called upon if needed.
As reported by La Gazzetta dello Sport, Radja Nainggolan, Marcelo Brozovic and Ivan Perisic all picked up injuries at the weekend, and coupled with the fact that Roberto Gagliardini isn't eligible to play in the Champions League, it could leave the Italian tactician severely short of options in midfield.
As Real Madrid are proving in the absence of Cristiano Ronaldo, a striker's goals are hard to replace but so too is the aura.
"When (Messi) is with us he gives us a sense of security", Barcelona defender Gerard Pique said.
On that day, Julio Baptista scored the only goal of the game to collect all three points for Bernd Schuster's side.
In his absence, Barcelona will start with Luis Suarez up front supported by Philippe Coutinho and Ousmane Dembele of either side. "But we've played without him in the past". Suarez buried the penalty.
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Luke Shaw earned himself a new contract at Manchester United , prompting Jose Mourinho to praise the defender for his attitude. We conceded from two set-pieces, but that is a way to score goals and you have to be able to defend against that.
He's the team's leading scorer with seven goals in the league after nine matches.
Valverde is under no illusions about the challenges ahead without his talisman but suggested Messi's absence may allow other players to step up.
The Spanish champions went into the fixture, knowing that victory would open up a four-point gap, after Real Madrid were beaten 2-1 by Levante earlier in the day.
They face Viktoria Plzen on Tuesday before visiting Barcelona next Saturday and a defeat by their greatest rivals might well see Lopetegui axed by club president Florentino Perez. We attacked a lot and looked unsafe.
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Trump has blamed the market's big sell-off on rising rates and has described the Fed as being "out of control". Earlier this month, Trump said he thought the Fed was "making a mistake" by raising interest rates.