Winners will have up to one year to claim their prize, depending on where they purchased their ticket.
Clerks at gas stations say extra help is brought in when jackpots get this astronomical and that rush hour is when lines are the longest.
The odds of winning the $1.6 billion jackpot are now 1 in 302,575,350, but that hasn't stopped thousands, if not millions, of people from playing across the country.
The deadline for buying tickets in most states is 10:45 p.m. EST, or 15 minutes ahead of the drawing, though some stop sales earlier.
Mega Millions jackpot rolls over with prize now at $1,600,000,000
But someone is over $38,000 richer this morning after purchasing a winning Florida Lottery Fantasy 5 ticket in Davisville. The current Mega Millions jackpot has been growing since July, when a group of California office workers won $543m.
Another added a hopeful note to their tweet, writing, "I didn't win #MegaMillions this time". (Cheer up, though, it was 25% past year!) Assuming the Mega Millions jackpot doesn't go up and you take the $904 million lump sum payment, that works out to just about $217 million automatically deducted. She points out that some people don't necessarily play to win.
The biggest quirk starts with this fact: The advertised $1.6 billion Mega Millions prize - the world's largest ever lottery jackpot - and $620 million Powerball prize aren't quite real. In California, for example, the lottery sold $5.7m in Mega Millions tickets during the first half of the day on Thursday.
Each Powerball or Mega Millions ticket is $2. While a billion is nice, if a lucky victor decided they didn't want to wait and took the cash option, they would have to make due with just $905 million.
"We all said we'd turn in our resignation at the same time", she said, laughing. Here are some answers for someone holding that prized lottery ticket for what would be the largest lottery jackpot in US history. "Like today ... every single sale I've had has literally had a Mega Millions ticket attached to it". If they like privacy, they could buy their own private island.
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While the 33-year-old has flashed upside this season, it's going to be worth watching to see what he can do as the go-to receiver. The former Texas standout's first season with Dallas was his best, with 596 yards receiving and seven touchdowns.
"I have no idea", Garcia said about what'd he buy if he wins.
Just stop somewhere - a coffee shop, the grocery store checkout, or your office - and listen.
"The important thing is you have to make sure that you pay attention to the inventory, and if you do that, you'll be surprised at what it'll do for you down the road", said Musto, Musto Tax and Insurance Services.
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For example, if the USA were to halt or reduce production, the implications would be big because the price increase could be high. Brent crude oil has now dropped below $80 a barrel.