The senator is the twelfth of thirteen Democratic candidates to enter the 2020 presidential race.
After falling short in 2016 against Hillary Clinton, Sanders told supporters at a rally at Brooklyn College, which he once attended, that his campaign is saying "loudly and clearly that the underlying principles of our government will not be greed, hatred and lies".
"I know where I came from!" he howled, a hint of exuberance in his voice.
"And that is something I will never forget", he said to an audience who broke out with chants of "Bernie, Bernie, Bernie".
Sanders' speech was very similar to that given in Brooklyn the day before, in which he outlined a series of limited reforms without explaining how any of these could actually be implemented given the hostility of the USA ruling elite, including the leaders of the Democratic Party whose presidential nomination he is seeking.
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"My mother's dream was that someday our family would move out of that rent-controlled apartment to a home of our own".
"I came from a family who knew all too well the frightening power employers can have over every day workers", he added.
Sanders was on "The View" to talk about his campaign for president, which is now about a week and a half old.
Jeff Weaver, a top adviser to Sanders, said the weekend's events were "an attempt to draw a connection between Bernie Sanders' life story and the policy agenda that he is putting forward in the campaign".
But even as Sanders broadened the scope of his stump speech to include more details about his youth, his message never strayed far from the core argument that would vault him to political stardom decades later. Though the two have been friends since before they came to the Senate, Warren did not endorse Sanders in 2016, a decision that angered his supporters. After that, Sanders heads to Chicago for a Sunday nightrally at Navy Pier.
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Trump let loose against House Democrats broadening their investigations of him, predicted he would win re-election by a greater margin that his 2016 victory, taunted some of his potential White House challengers and sounded themes that are staples of his rallies.
A number of the liberal positions that Sanders has championed, in some cases for years, have been backed by other Democrats in the field, notably Massachusetts Sen.
"Have we made progress in civil rights in this country since the early 1960s when I lived here? This is hopeful. People come and they hear what's broken, that we can fix it and that we do it together".
During an interview with "The Breakfast Club", Sanders explained how he will be able to follow through with his long list of promises to the American people, including tuition-free college, "Medicare-for-all", and an economic overhaul to combat climate change.
Sanders said he became involved at that time with the Congress on Racial Equality, or CORE, and helped fight segregated housing at the University of Chicago. One of the challenges Mr Sanders faces is that the Democratic Party has shifted to the left, making his message less distinctive, BBC North America reporter Anthony Zurcher says.
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Sander's Saturday speech saw various reactions among social media users. He regularly describes the President as a "racist and xenophobe", and once again in Brooklyn warned against allowing "Trump and his friends to divide us up".